At SCH, Mike was a two-time All-Inter-Ac pitcher. He was voted First Team All-City as a senior named to the 30-Year All-Inter-Ac All-Star Team. In 1998, Mike helped lead the University of Delaware to the America East Conference baseball championship. After college, he was drafted by the Arizona Diamondbacks, and was part of their 2001 World Series Championship team. Following six seasons with the Diamondbacks, he played briefly for the Cleveland Indians in 2007, concluding his major league career as a sidearm pitcher with 15-7 wins, a 3.82 ERA, and 175 strikeouts.
In 2008 he was selected to compete in the Beijing Summer Olympics where the U.S. team won a bronze medal. He was the only American pitcher to not give up a hit, pitching 5 1/3 scoreless innings in four appearances, and striking out six batters. After the Olympics, Koplove played in the minor leagues for three years before retiring and turning his attention to scouting. Mike is a 2010 inductee of the CHA Athletic Hall of Fame, a 2019 inductee of the Philadelphia Sports Jewish Hall of Fame, and a 2020 inductee of the City All-Star Chapter Pennsylvania Sports Hall of Fame.